Ependymomas develop within the ependymal cells lining the brain's ventricles (a series of fluid filled cavities in the brain). These tumours have the capacity to metastasize to other parts of the brain and spine (approximately 10%). The treatment involves maximum possible surgical resection of tumour, followed by radiation therapy or chemotherapy (Cyclophosphamide, Cisplatin, Methotrexate, Etoposide, Vincristive, Carboplatin) for very young children. The extent of resection of the tumour is the most important prognostic factor and therefore in case of residual tumour following the first operation repeat surgery is always at least considered, after a few cycles of chemotherapy.

The prognosis is fair. For patients who experience relapse (re-growth of the tumour) depending on the location surgery, and radiation or novel promising therapies are offered.