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Dr Zacharoulis has a major interest in childhood tumour angiogenesis: how tumours create their
own blood vessels. While in New York, he and his colleagues in Dr Lyden's laboratory provided evidence that as soon as a tumour
forms, it gives a signal to the bone marrow to "send" endothelial cells in the future metastatic organs (lungs , bone etc ) to
create "niches" for the tumour cells to arrive and grow secondary deposits. This work was published in Nature 438, 820-827
(8 December 2005).
Currently his research with colleagues at the Royal Marsden Hospital is focusing on translating the biology of angiogenesis into
treatment for childhood tumours: new drugs that stop the growth of blood vessels of tumours. This
research is already showing promise in adults with cancer being tested in the laboratory and in early clinical
trials. Moreover Dr Zacharoulis and his colleagues are trying to identify the patients who will respond
to such treatment or relapse based on blood tests.
For further information or to support this research please call 0208 6613498.
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